Infectious Salmon Anemia Virus

A small project about ISAVirus brought to you by a group of Year 2 MBIO students from Ngee Ann Polytechnic.

Click on the pastel orange box on the left for the names of the students involved in this project.

Thank you.

:)

Key Proteins
Thursday, 26 January 2012 @ 12:45
  1. A 38-43 kDa Hemagglutinin erastase(HE)(a surface glycoprotein)- Responsible for viral attachment and release(receptor binding and receptor destroying enzyme activities(RDE activity)(performed by neuraminidase))
  2. Major surface proteins: a 50kDa(a protein encoded by gene segment 5). Functions: responsible for fusion of viral and cellular membranes
  3. Tyrosine protein kina FRK: stimulation and suppression of cell proliferation
  4. D-type cyclins: coupling of extracellular cues with the regulation of cell cycle, govern entrance and progression through G1 phase via phosphorylation of antiproliferation retinoblastoma protein(protein is inactivated to allow for cell proliferation)
  5. Histone deacetylase-1 and high mobility group protein 2(hmgb2): Biosynthesis of nucleotides and regulation of transcription at different levels.
  6. Enzyme inhibition studies indicate that the acetylesterase of the ISAV HE contains a serine in its active site.
  7. The acetylesterase responsible for the RDE activity allows the virus to detach (elute) from these erythrocytes.
  8. The ISAV protein with highest sequence variation is the HE containing a highly polymorphic region (HPR) in the stalk of the protein, near the transmembrane domain.
  9. HPR0(no deletions)-> Found in healthy wild atlantic salmon fishes
  10. HPR(has differential deletions)->Found in infected  atlantic salmon fishes
  11. Therefore it is concluded  that variations in the length of the HPR may affect the structure of the molecule(whether it is infectious or not).